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Minoxidil- NOXIRIN

Minoxidil- NOXIRIN
Minoxidil- NOXIRIN
Product Code : MN 02
Product Description

Minoxidil – 5 Mg Tablet :- NOXIRIN ™

Noxirin ™

Minoxidil tablets, USP

WARNINGS

NOXIRIN ™ Tablets contain the powerful antihypertensive agent, minoxidil, which may produce serious adverse effects. It can cause pericardial effusion, occasionally progressing to tamponade, and angina pectoris may be exacerbated. NOXIRIN ™ should be reserved for hypertensive patients who do not respond adequately to maximum therapeutic doses of a diuretic and two other antihypertensive agents.

In experimental animals, minoxidil caused several kinds of myocardial lesions as well as other adverse cardiac effects (see Cardiac Lesions in Animals).

NOXIRIN ™ must be administered under close supervision, usually concomitantly with therapeutic doses of a beta-adrenergic blocking agent to prevent tachycardia and increased myocardial workload. It must also usually be given with a diuretic, frequently one acting in the ascending limb of the loop of Henle, to prevent serious fluid accumulation. Patients with malignant hypertension and those already receiving guanethidine (see WARNINGS) should be hospitalized when NOXIRIN ™ is first administered so that they can be monitored to avoid too rapid, or large orthostatic, decreases in blood pressure.

DESCRIPTION

NOXIRIN ™ Tablets contain minoxidil, an antihypertensive peripheral vasodilator. Minoxidil occurs as a white or off-white, odorless, crystalline solid that is soluble in water to the extent of approximately 2 mg/mL, is readily soluble in propylene glycol or ethanol, and is almost insoluble in acetone, chloroform or ethyl acetate. The chemical name for minoxidil is 2,4-pyrimidinediamine,6-(1-piperidinyl)-, 3-oxide (mw=209.25).

The structural formula is represented at right:

NOXIRIN ™ Tablets for oral administration contain either 2.5 mg or 10 mg of minoxidil. Inactive ingredients: cellulose, corn starch, lactose, magnesium stearate, silicon dioxide.

Unapproved Use

Use of NOXIRIN ™ Tablets, in any formulation, to promote hair growth is not an approved indication. While clinical trials with ROGAINE® Topical Solution 2% demonstrated that formulation and dosage were safe and effective, the effects of extemporaneous formulations and dosages have not been shown to be safe or effective. Because systemic absorption of topically applied drug may occur and is dependent on vehicle and/or method of use, extemporaneous topical formulations made from NOXIRIN ™ should be considered to share in the full range of CONTRAINDICATIONS, WARNINGS, PRECAUTIONS, and ADVERSE REACTIONS listed in this insert. In addition, skin intolerance to drug and/or vehicle may occur.


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  • Contact Details
  • Jonakayem Pharma Formulation (OPC) Pvt. Ltd.
  • 2, The Greenfield Chs Ltd, L.M. Road, Marian Colony, Borivali (W), Mumbai - 400103, Maharashtra, India
  • Phone : +919069143664
  • Fax : 91-22-28907454
  • Mr. Navneet Sahay Verma (M.D.)
  • Mobile : +919069143664
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